Tocotrienol Rich Fraction Reverses Age-Related Deficits in Spatial Learning and Memory in Aged Rats

Little is known about the effect of vitamin E on brain function. Therefore, in this study we evaluated the effect of tocotrienol rich fraction (TRF) on behavioral impairment and oxidative stress in aged rats. Thirty-six male Wistar rats (young: 3-months-old; aged: 21-months-old) were treated with either the control (olive oil) or TRF (200 mg/kg) for 3 months. Behavioral studies were performed using the open field test and Morris water maze (MWM) task. Blood was taken for assessment of DNA damage, plasma malondialdehyde (MDA) and vitamin E, and erythrocyte antioxidant enzyme activity. Brains were also collected to measure vitamin E levels. Results showed that aged rats exhibited reduced exploratory activity, enhanced anxiety and decreased spatial learning and memory compared with young rats. DNA damage and plasma MDA were increased, and vitamin E levels in plasma and brain were reduced in aged rats. Aged rats supplemented with TRF showed a markedly reduced level of anxiety, improved spatial learning and memory, reduced amount and severity of DNA damage, a reduced level of MDA, and increased levels of antioxidant enzyme activity and plasma/brain vitamin E compared with age-matched controls. In conclusion, TRF supplementation reverses spatial learning and memory decline and decreases oxidative stress in aged rats.     

《微生物技术》课程教学改革的研究

文章通过对微生物技术课程的项目化教学改革研究,提高了课程的实践应用性,通过考核方式的改革提高了学生的积极性,以及解决问题分析问题的能力和团队协作的能力。     

Equations to predict female manual arm strength based on hand location relative to the shoulder

The purpose of this study was to develop regression equations to predict manual arm strength for a wide variety of hand locations within the reach envelope. Maximum voluntary manual arm strength was determined from 71 female participants in six exertion directions (superior, inferior, anterior, posterior, medial and lateral), in a total of 28 hand locations. Forces ranged from 51.3 to 164.4 N, and had a pooled coefficient of variation of 29.9%. Across all 168 combinations of hand locations and exertion directions, the multivariate regression equations explained 92.5% of the variance and had a root mean square error (RMSE) of only 6.4 N, using only the anterior, lateral and vertical location of the hand relative to the active shoulder joint as inputs. These equations provide a proof-of-principle for our novel regression approach, and represent a first step towards a more comprehensive equation to estimate maximum acceptable forces for occupational tasks.     

Analytical modeling of Transmission Control Protocol NewReno using Generalized Stochastic Petri Nets

This paper presents a novel analytical model of Transmission Control Protocol (TCP) using a generalized stochastic Petri net (GSPN). Extensive simulation work has been done for the performance evaluation of TCP NewReno protocol. In view of the limitations of the simulation technique, we present an analytical approach using GSPN. A GSPN is a useful mathematical tool that solves continuous time Markov chains for complex systems and evaluates the stationary behavior. In this paper, we analyze the slow‐but‐steady variant of TCP NewReno. The model captures the behavioral aspects of the slow start and the congestion avoidance phase together with the fast retransmit and recovery capabilities of TCP NewReno. Performance metrics such as throughput, goodput, and task completion time of the system are obtained. The effect of variation in the model parameters on the performance is studied. The results are validated using the network simulator, and their accuracy is verified by evaluating the confidence interval. The performance of the proposed model is compared with that of TCP Reno. The performance of the proposed model is also compared with one of the previous models. The numerical illustrations and comparison of the proposed technique with simulation validates the accuracy, efficiency, and competence of the GSPN technique. While GSPN modeling for TCP is investigated in depth for the TCP NewReno and TCP Reno variant in this paper, other protocols could be also analyzed similarly. Copyright © 2013 John Wiley & Sons, Ltd.     

Optimal capacity design of battery and hydrogen system for the DC grid with photovoltaic power generation based on the rapid estimation of grid dependency

This paper presents a fast and novel method to determine the optimal capacity of a battery and a hydrogen system for a grid-connected photovoltaic (PV) system based on the required grid dependency (GD) and the minimum Levelized Cost of Energy (LCE). The GD is calculated from the weather data at 9 locations throughout Japan during 25 years considering different sizing of PV, battery, and hydrogen system. Based on the results, the relationship between the GD and the capacities of the devices and the weather parameter is established. The results show that the GD depends on the annual total solar insolation and the devices’ capacities as well. The empirical GD formula is then examined at a different location in Japan. The proposed GD calculation agrees well with the GD obtained from the real 25 – year weather data and shows great advantages over the conventional method in the simplicity and calculation time. In addition, the optimal capacity of the system can be obtained directly from the GD formula and the objective function of the LCE.     

大数据流式计算框架Heron环境下的流分类任务调度策略

新型大数据流式计算框架Apache Heron默认使用轮询调度算法进行任务调度，忽略了拓扑运行时状态以及任务实例间不同通信方式对系统性能的影响。针对这个问题，提出Heron环境下流分类任务调度策略（DSC-Heron），包括流分类算法、流簇分配算法和流分类调度算法。首先通过建立Heron作业模型明确任务实例间不同通信方式的通信开销差异；其次基于流分类模型，根据任务实例间实时数据流大小对数据流进行分类；最后将相互关联的高频数据流整体作为基本调度单元构建任务分配计划，在满足资源约束条件的同时尽可能多地将节点间通信转化为节点内通信以最小化系统通信开销。在包含9个节点的Heron集群环境下分别运行SentenceWordCount、WordCount和FileWordCount拓扑，结果表明DSC-Heron相对于Heron默认调度策略，在系统完成时延、节点间通信开销和系统吞吐量上分别平均优化了8.35%、7.07%和6.83%；在负载均衡性方面，工作节点的CPU占用率和内存占用率标准差分别平均下降了41.44%和41.23%。实验结果表明，DSC-Heron对测试拓扑的运行性能有一定的优化作用，其中对接近真实应用场景的FileWordCount拓扑优化效果最为显著。     

BUILDING USER TASK SPACE BY MINING TEMPORALLY PROXIMATE DESKTOP ACTIONS

Awareness of the user's current context, that is, the task the user resides in, can allow for various ways of supporting their work. In this article we present a novel approach for mining user's regular tasks on the basis of temporal proximity of users’ desktop actions without user intervention in a completely automatic, unobtrusive, and unsupervised manner. The proposed method is based on time-based clustering of a user's desktop actions and, in contrast to previous approaches, it does not enforce fixed time constraints on the mined actions, and typical transition times, when they exist, emerge from the logged activity data for that specific user. The performance of our technique was evaluated on a large data set of 724 days of desktop work by five knowledge workers. The results showed that our approach performed very well and was able to cluster those temporally proximate user actions that commonly used fix time window techniques fail to deal with. Notably, the main improvement is in the recall of the tasks, where our approach recalled 10.18% more actions than the predefined time window technique.     

I/O-efficient join dependency testing,Loomis–Whitney join,and triangle enumeration

We revisit two fundamental problems in database theory. The join-dependency (JD) testing problem is to determine whether a given JD holds on a relation r. We prove that the problem is NP-hard even if the JD involves only relations each of which has only two attributes. The JD-existence testing problem is to determine if there exists any non-trivial JD satisfied by r. We present an I/O-efficient algorithm in the external memory model, which in fact settles the closely related Loomis–Whitney enumeration problem. As a side product, we solve the triangle enumeration problem with the optimal I/O-complexity, improving a recent result of Pagh and Silvestri in PODS'14.     

Thickness dependent barrier performance of permeation barriers made from atomic layer deposited alumina for organic devices

Organic devices like organic light emitting diodes (OLEDs) or organic solar cells degrade fast when exposed to ambient air. Hence, thin-films acting as permeation barriers are needed for their protection. Atomic layer deposition (ALD) is known to be one of the best technologies to reach barriers with a low defect density at gentle process conditions. As well, ALD is reported to be one of the thinnest barrier layers, with a critical thickness – defining a continuous barrier film – as low as 5–10 nm for ALD processed Al₂O₃. In this work, we investigate the barrier performance of Al₂O₃ films processed by ALD at 80 °C with trimethylaluminum and ozone as precursors. The coverage of defects in such films is investigated on a 5 nm thick Al₂O₃ film, i.e. below the critical thickness, on calcium using atomic force microscopy (AFM). We find for this sub-critical thickness regime that all spots giving raise to water ingress on the 20 × 20 μm² scan range are positioned on nearly flat surface sites without the presence of particles or large substrate features. Hence below the critical thickness, ALD leaves open or at least weakly covered spots even on feature-free surface sites. The thickness dependent performance of these barrier films is investigated for thicknesses ranging from 15 to 100 nm, i.e. above the assumed critical film thickness of this system. To measure the barrier performance, electrical calcium corrosion tests are used in order to measure the water vapor transmission rate (WVTR), electrodeposition is used in order to decorate and count defects, and dark spot growth on OLEDs is used in order to confirm the results for real devices. For 15–25 nm barrier thickness, we observe an exponential decrease in defect density with barrier thickness which explains the likewise observed exponential decrease in WVTR and OLED degradation rate. Above 25 nm, a further increase in barrier thickness leads to a further exponential decrease in defect density, but an only sub-exponential decrease in WVTR and OLED degradation rate. In conclusion, the performance of the thin Al₂O₃ permeation barrier is dominated by its defect density. This defect density is reduced exponentially with increasing barrier thickness for alumina thicknesses of up to at least 25 nm.     

基于任务驱动的电动机自锁PLC控制教学设计

PLC是一门实践性很强的机电一体化技术专业的核心课程,而任务驱动教学法的使用能更好地实现该课程的教学目的。因此,基于任务驱动的PLC教学设计是PLC课堂教学中实施任务驱动教学法的关键。文章针对该课程中电动机自锁PLC控制这一任务,进行教学设计的探讨。